1-2 Punch to Type II Diabetes’ Face

Here is a study I found today about the effects of a well placed weight loss plan implemented on patients with Type 2 Diabetes, this is something I really care about and one of the reasons that I myself take part in helping people lose weight. This study done recently had some really great results.

Metabolic Changes Following a One-year Diet and Exercise Intervention in Patients with Type 2 Diabetes.

Albu JB, Heilbronn LK, Kelley DE, Smith SR, Azuma K, Berk E, Pi-Sunyer FX, Ravussin E; the Look AHEAD Adipose Research Group.

Department of Medicine, St. Luke’s -Roosevelt Hospital Center, Columbia University, New York, NY, 10025.


Objective:To characterize the relationships between long-term improvements in peripheral insulin sensitivity (glucose disposal rate=GDR), fasting glucose (FG) and free fatty acids (FFA-s), and concomitant changes in weight and adipose tissue (AT) mass and distribution induced by lifestyle-intervention in obese individuals with type 2 diabetes.


Research Design and Methods: We measured GDR, FG and FFA-s during aeuglycemic clamp, and AT mass/distribution, organ fat and adipocytesize by DXA, CT scan and AT biopsy in 26 men and 32 women in the Look-AHEAD trial before and after 1 year of diet and exercise aimed at weight loss.

Results: Weight and FG decreased significantly(P<0.0001) and significantly more in men than in women (-12% vs. -8%and -16% vs. -7%, P<0.05) while FFA-s during hyperinsulinemia decreased and GDR increased significantly (P<0.00001), similarly in both sexes (-53% vs. -41% and +63% vs. +43%, P = NS). Men achieved a more favorable fat distribution by losing more from upper compared to lower and from deeper compared to superficial AT depots (P<0.01). Decreases in weight and AT mass predicted improvements in GDR, but not in FG or fasting FFA-s; however decreases in FFA-s during hyperinsulinemia significantly determined GDR improvements. Hepatic fat was the only regional fat measure whose change contributed independently to changes in metabolic variables.

Conclusions: Patients with type 2 diabetes undergoing a one-year lifestyle-intervention hads ignificant improvements in GDR, FG, FFA-s and AT distribution.However, changes in overall weight (AT mass) and hepatic fat were the most important determinants of metabolic improvements.

So what this means is, even if you do have a dangerous complication like Type 2 Diabetes you can still do a lot to improve your health and give yourself a fighting chance to live longer and be healthier.

For More Infomation on Type 2 Diabetes here is a good bit of info by Brown University.

Knowledge is power, and an important step in overcoming diabetes and other metabolic syndromes.

It is not over til it’s over.

Waging War on Bodyfat!

John David Reynolds III, CPT

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